Matches in SemOpenAlex for { <https://semopenalex.org/work/W2364631878> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2364631878 abstract "Objective To explore the feasibility and safety of loading dose of clopidogrel treatment in patients with non cardiaoembolic acute ischemic stroke / transient ischemic attack(TIA).Methods A multicenter,prospective,randomized,controlled parallel clinical trial was conducted to evaluate the feasibility and safety.Patients with non cardiaoembolic ischemic stroke or TIA within 48 h were randomized into load dose(300mg followed by daily 75 mg) or standard dose(daily 75 mg) clopidogrel group,respectively,and followed up for 90 days.Primary outcome was progressive or recurrent stroke within 7 d.Second outcomes included dead or dependent(modified Rankin Scale,mRS2),favorable outcome(mRS 0~1 or Barthel Index 95~100) at 90 d and efficacy(NIHSS improvement ≥18%) at 28 d.Life threatening bleeding was used as primary safety endpoint.Results From July 2005 to March 2006,a total of 71 patients from 3 centers were enrolled and completed follow-up.Compared with non-loading dose treatment,loading clopidogrel treatment had a relative risk reduction(RRR) of 55.8%(95% CI:-14.2~82.9%,P=0.077) for progressive or recurrent rate within 7 d,35.2%(95% CI:-39.2~69.8%,P=0.259) for death or dependence at 90 d.The efficacy at 28 d and the favorable outcome at 90 d were slightly better in patients treated with loading dosage clopidogrel(P0.05).No life-threatening bleeding was found in all patients and no difference in safety of this drug was found between the two groups.Compared with the data from 3 randomized double blind clinical trials with aspirin,a favorable trend was suggested in loading dose clopidogrel treatment.Conclusions The load dose clopidogrel seems to be safe and effective in treating non cardioembolic acute ischemic stroke/TIA,which merits further study." @default.
- W2364631878 created "2016-06-24" @default.
- W2364631878 creator A5022274021 @default.
- W2364631878 date "2008-01-01" @default.
- W2364631878 modified "2023-09-23" @default.
- W2364631878 title "A Pilot Trial of Clopidogrel of Loading Dosage to Treat non Cardiaoembolic Acute Ischemic Stroke /Transient Ischemic Attack in China(CLASS-CHINA Pilot)." @default.
- W2364631878 hasPublicationYear "2008" @default.
- W2364631878 type Work @default.
- W2364631878 sameAs 2364631878 @default.
- W2364631878 citedByCount "0" @default.
- W2364631878 crossrefType "journal-article" @default.
- W2364631878 hasAuthorship W2364631878A5022274021 @default.
- W2364631878 hasConcept C126322002 @default.
- W2364631878 hasConcept C127413603 @default.
- W2364631878 hasConcept C168563851 @default.
- W2364631878 hasConcept C1862650 @default.
- W2364631878 hasConcept C197934379 @default.
- W2364631878 hasConcept C203092338 @default.
- W2364631878 hasConcept C2775965419 @default.
- W2364631878 hasConcept C2777849778 @default.
- W2364631878 hasConcept C2780645631 @default.
- W2364631878 hasConcept C2780931571 @default.
- W2364631878 hasConcept C2991681754 @default.
- W2364631878 hasConcept C2992435398 @default.
- W2364631878 hasConcept C3020199598 @default.
- W2364631878 hasConcept C42219234 @default.
- W2364631878 hasConcept C500558357 @default.
- W2364631878 hasConcept C535046627 @default.
- W2364631878 hasConcept C541997718 @default.
- W2364631878 hasConcept C71924100 @default.
- W2364631878 hasConcept C78519656 @default.
- W2364631878 hasConcept C79544238 @default.
- W2364631878 hasConceptScore W2364631878C126322002 @default.
- W2364631878 hasConceptScore W2364631878C127413603 @default.
- W2364631878 hasConceptScore W2364631878C168563851 @default.
- W2364631878 hasConceptScore W2364631878C1862650 @default.
- W2364631878 hasConceptScore W2364631878C197934379 @default.
- W2364631878 hasConceptScore W2364631878C203092338 @default.
- W2364631878 hasConceptScore W2364631878C2775965419 @default.
- W2364631878 hasConceptScore W2364631878C2777849778 @default.
- W2364631878 hasConceptScore W2364631878C2780645631 @default.
- W2364631878 hasConceptScore W2364631878C2780931571 @default.
- W2364631878 hasConceptScore W2364631878C2991681754 @default.
- W2364631878 hasConceptScore W2364631878C2992435398 @default.
- W2364631878 hasConceptScore W2364631878C3020199598 @default.
- W2364631878 hasConceptScore W2364631878C42219234 @default.
- W2364631878 hasConceptScore W2364631878C500558357 @default.
- W2364631878 hasConceptScore W2364631878C535046627 @default.
- W2364631878 hasConceptScore W2364631878C541997718 @default.
- W2364631878 hasConceptScore W2364631878C71924100 @default.
- W2364631878 hasConceptScore W2364631878C78519656 @default.
- W2364631878 hasConceptScore W2364631878C79544238 @default.
- W2364631878 hasLocation W23646318781 @default.
- W2364631878 hasOpenAccess W2364631878 @default.
- W2364631878 hasPrimaryLocation W23646318781 @default.
- W2364631878 hasRelatedWork W1735396177 @default.
- W2364631878 hasRelatedWork W175089505 @default.
- W2364631878 hasRelatedWork W1879080173 @default.
- W2364631878 hasRelatedWork W2053379248 @default.
- W2364631878 hasRelatedWork W2081615170 @default.
- W2364631878 hasRelatedWork W2082617878 @default.
- W2364631878 hasRelatedWork W2097910670 @default.
- W2364631878 hasRelatedWork W2121298865 @default.
- W2364631878 hasRelatedWork W2132247347 @default.
- W2364631878 hasRelatedWork W2340107191 @default.
- W2364631878 hasRelatedWork W2353771354 @default.
- W2364631878 hasRelatedWork W2379170702 @default.
- W2364631878 hasRelatedWork W2529886764 @default.
- W2364631878 hasRelatedWork W2696116946 @default.
- W2364631878 hasRelatedWork W2804520941 @default.
- W2364631878 hasRelatedWork W2804570339 @default.
- W2364631878 hasRelatedWork W2806020159 @default.
- W2364631878 hasRelatedWork W2926542596 @default.
- W2364631878 hasRelatedWork W3030661466 @default.
- W2364631878 hasRelatedWork W3127180430 @default.
- W2364631878 isParatext "false" @default.
- W2364631878 isRetracted "false" @default.
- W2364631878 magId "2364631878" @default.
- W2364631878 workType "article" @default.