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- W2364634511 abstract "Objective To explore the changes of Fas ligand (FasL) and caspase 8 during the apoptotic process of human lymphoma Jurkat T cells induced by Tripterygium hypoglaucum (Levl) Hutch (THH) alkaloids to study the molecular mechanisms of the apoptosis. Methods After Jurkat cells were induced by THH alkaloids, translocated phosphatidylserine was labeled with Annexin V Fluorescence; the apoptotic incidence was measured by flow cytometry; changes of the expressions of FasL, Bid, caspase 7 and caspase 8 proteins were determined by Western blotting. Results THH alkaloids could effectively induce the apoptosis of Jurkat cells. FasL expression was increased and caspase 8, caspase 7 and Bid were activated in a time dependent manner after treatment with THH alkaloids. Conclusion THH alkaloids induce the apoptosis of Jurkat cells via the activation of caspase 7 and Bid through the FasL mediated activation of caspase 8." @default.
- W2364634511 created "2016-06-24" @default.
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- W2364634511 date "2003-01-01" @default.
- W2364634511 modified "2023-09-26" @default.
- W2364634511 title "Tripterygium hypoglaucum (Levl) Hutch alkaloids induce apoptosis of Jurkat lymphoma cells via the Fas receptor-mediated pathway" @default.
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