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- W2364644102 abstract "AIM To compare the efficacy and safety of linezolid with glycopeptides in patients with Grampositive cocci infections by a meta-analysis of randomized controlled trials published in English and Chinese literatures.METHODS The data were collected from the MEDLINE,EMBASE,OVID,the Cochrane library,and CNKI database,and the references of eligible studies were manually screened.Randomized controlled trials published in English and Chinese literatures comparing linezolid with glycopeptides in patients with Gram-positive cocci infections were included and meta-analyzed.RESULTS Fourteen randomized controlled studies comparing linezolid with glycopeptides were analyzed,focusing on 6 495 patients with Gram-positive cocci infections.It was found by meta-analysis that,linezolid was more effective than glycopeptides in clinical treatment success for clinically evaluation patients at the end-of-treatment visit(RR = 1.11,95%CI(1.05,1.16),P 0.000 1),and it was more effective than glycopeptides for intention-to-treat patients at the test-of-cure visit(RR = 1.05,95%CI(1.00,1.09),P = 0.03).Linezolid was more effective than glycopeptides in microbiological treatment success(RR = 1.07,95%CI(1.03,1.12),P = 0.000 6),as well as in Staphylococcus aureus eradication(RR = 1.12,95%CI(1.03,1.23),P = 0.01) for microbiologically evaluation patients at the test-of-cure visit,but,there was no difference for methicillin-resistant Staphylococcus aureus eradication(RR = 1.10,95%CI(0.99,1.23),P = 0.07).Adverse reaction rates(RR = 1.09,95%CI(0.98,1.21),P = 0.10) was similar between the two drugs,but the rate of abnormal renal function(RR =0.41,95%CI(0.23,0.73),P= 0.003) was lower in patients receiving linezolid,and thrombocytopenia(RR =9.53,95%CI(3.86,23.56),P 0.000 01) was recorded more commonly in patients receiving linezolid.CONCLUSION Linezolid is more effective than glycopeptides for treatment of patients with Gram-positive cocci infections with similar safety and less renal toxicity,but the higher probability of thrombocytopenia may limit its use to Gram-positive cocci infections that are difficult to treat with other antibiotics." @default.
- W2364644102 created "2016-06-24" @default.
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- W2364644102 date "2013-01-01" @default.
- W2364644102 modified "2023-09-26" @default.
- W2364644102 title "Linezolid versus glycopeptides for treatment of Gram-positive cocci infections:a meta-analysis of randomised controlled trials" @default.
- W2364644102 hasPublicationYear "2013" @default.
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