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- W2364648639 abstract "Objective To observe the immune effect of recombinant outer surface protein(rOspA) of Chinese Borrelia garinii in animals and provide a basis for the development of rOspA vaccine.Methods Immunize New Zealand rabbits,sheep and dogs with purified rOspA at different dosages.Determine the serum specific IgG by IFA and perform neutralization test in vitro.Results The serum IgG titers of the animals increased significantly compared with those before immunization and could still be detected 6 months after immunization.Neutralization test in vitro proved that each milliliter of rabbit anti-rOspA serum could kill 10~5 Lyme disease spirochetes,however,the killing capacities of anti-rOspA sera of sheep and dog immunized with various dosages of rOspA were also different.Each milliliter of sheep or dog anti-rOspA serum could kill 10~6 Lyme disease spirochetes at most.Conclusion rOspA showed good immune protection and might be an effective component of Lyme disease rOspA subunit vaccine in China." @default.
- W2364648639 created "2016-06-24" @default.
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- W2364648639 date "2005-01-01" @default.
- W2364648639 modified "2023-09-22" @default.
- W2364648639 title "Immune Effect of Recombinant Outer Surface Protein(rOspA) of Chinese Borrelia garinii PD91 in Animals" @default.
- W2364648639 hasPublicationYear "2005" @default.
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