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- W2364650078 abstract "Aim: To investigate the protective effects of sulfasalazine(SSA) on transplanted rat heart. Methods:A rat heterotopic cardiac transplant model with SD donors and Wistar recipients was used.Three groups in total: control group of Wistar to Wistar rat heart transplantation, group of SD to Wistar rat heart transplantation, group of SD to Wistar rat heart transplantation and treated with SSA. At 3 d,5 d,and 7 d after operation,harvested grafts received immunohistochemical and histopathological examinations to examine the expression of ICAM-1 and acute rejection. Radioimmunoassay and multimedia pathology imaging analysis system were used for quantitative measurement of IL-1β and ICAM-1 expression.Results: Faint expression of IL-1βand ICAM-1 at different time points in control group was found; in heterotopic transplantation group, IL-1β and ICAM-1 contents significantly elevated(P0.05); after treatment with SSA, IL-1β and ICAM-1 contents significantly decreased(P0.01). In control group the cardiac tissue was nearly normal;in heterotopic transplantation group,infiltrated lymphocytes, myocardium stromatic edema, and tissue necrosis could be observed the injury of grafts was significantly relieved by SSA. Conclusion: SSA can suppress the excessive expression of IL-1β and ICAM-1 during the acute graft rejection and protect the transplanted rat hearts." @default.
- W2364650078 created "2016-06-24" @default.
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- W2364650078 date "2005-01-01" @default.
- W2364650078 modified "2023-09-26" @default.
- W2364650078 title "Effect of sulfasalazine on expression of inteleukin-1 beta and intercellular adhesion molecule-1 in acute rejection of rat heart transplantation" @default.
- W2364650078 hasPublicationYear "2005" @default.
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