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- W2364650521 abstract "Objective To assess the expression of Livin gene,a new member of the inhibitor of apoptosis protein family,in upper urinary tract transitional cell carcinoma(UTCC) and to indentified the relationship between tumor stage,tumor grade and relapse with its expression.Methods Immunohistochemical staining for livin was performed using paraffin-embedded tissues from 58 cases of UTCC and 12 normal tissue of upper urinary tract.Disease-specific survival of patients was assessed,the differences between the immunohistologically livin-positive and livin-negative groups was compared with recurrence-free survival using the Kaplan-Meier method and log-rank test.Results Of the 58 UTCC specimens,35(60.3%) showed positive staining of Livin immunohistochemically.There is no expression in normal upper urinary tract tissues.The expression of Livin gene were statistically similar in different age,sex and lymph node metastasis status groups(P0.05).Howerver,the positive expression rate of Livin gene of different tumor grade and stage groups showed a statistically difference(P0.05).The mean follow up was 29.3 months,the over all recurrence rate was 46.6%.For positive expression group,the 3-year estimate recurrence free survival rate was 30.1%,and 49.5% for the negtive expression group,the difference was significant(P0.05).Conclusion Livin gene can be detected in UTCC tissues,and its expression is correlated with the tumor stage,grade and tumor relapse,it may be recognized as a biomarker of UTCC." @default.
- W2364650521 created "2016-06-24" @default.
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- W2364650521 date "2012-01-01" @default.
- W2364650521 modified "2023-09-22" @default.
- W2364650521 title "The expression of Livin gene in upper urinary tract transitional cell carcinoma and its relation to the tumor relapse" @default.
- W2364650521 hasPublicationYear "2012" @default.
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