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- W2364651015 abstract "Prion is a highly conserved plasma membrane-anchored extracellular glycoprotein.It is widely distrib uted in the central nervous system and several peripheral tissues.The special organization and cellular localization of cellular isoform of prion protein(PrPC)would be consistent with a number of different functions,including sig nal transduction,cell adhesion,copper homeostasis,anti-apoptosis,antioxidant activity.Recently,prion is not just considered a pathogenic factor by studying the structure,physiological function and conversion mechanism of PrPC.New research has focused on the genetic evolution and physiological function of PrPC.The cellular localization,transport and tissue distribution of PrPC were reviewed in this paper.The physiologic function of PrPC in nervous system,tumorigenesis and embryonic development were then proposed.Additionally,we focused on the prospective outline on the study of this protein." @default.
- W2364651015 created "2016-06-24" @default.
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- W2364651015 date "2012-01-01" @default.
- W2364651015 modified "2023-09-25" @default.
- W2364651015 title "Research Progress of Physiologic Function of Prion Protein" @default.
- W2364651015 hasPublicationYear "2012" @default.
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