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- W2364651519 abstract "Objective In order to insure the successful use of L asparaginase(L ASP) in childhood lymphoblastic leukemia and non Hodgkin's lymphoma ,we observed the serious complications of L ASP. Methods We designed measurements and items to detect and monitor the complications of L ASP. The incidence and onset time of each complication were summarized. Results Twenty of 301 patients(6.6 %) developed serious complications which were most probably due to L ASP therapy . We observed 6 children (1.99 %) had pancreatitis. Hyperglycemia were observed in 7 patients (2.32 %). One patient developed hypoglycemia (0.33 %). Centralnevous system thrombosis were observed in 2 patients(0.66 %). Haemorrhagic and shock were observed in 4 and 15 patients separately. Six patients(1.99 %) developed DIC. Seven patients(2.3 %)developed shock .Ten patients(3.3 %) died of various complications. Conclusions The cytotoxic effect of L ASP may cause systemic damage to patients,even lethiferous.Close and reasonable monitoring and early interventions may decrease the incidence and hazard of the L ASP complications obviously." @default.
- W2364651519 created "2016-06-24" @default.
- W2364651519 creator A5080070785 @default.
- W2364651519 date "2003-01-01" @default.
- W2364651519 modified "2023-09-23" @default.
- W2364651519 title "Serious complications of L-asparaginase in children with lymphatic system maliganancy" @default.
- W2364651519 hasPublicationYear "2003" @default.
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