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- W2364652250 abstract "Telomerase plays a critical role in maintaining telomere length, and it is one of the markers of the tumors. A recombinant adenovirus vector,Ad-GFP-C197, was constructed to express intact C-terminus of human telomerase reverse transcriptase(amino acid 936-1132,C197), and its effect on the growth of Hela cells was evaluated. Western blot assay showed C197 were expressed in Hela cells after infection with AdGFP-C197. Furthermore, Ad-GFP-C197 significantly inhibited the proliferation and promoted apoptosis of Hela cells, as well as suppressed telomerase activity in Hela cells. The results highlight the potential of C-197 in tumor therapy." @default.
- W2364652250 created "2016-06-24" @default.
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- W2364652250 date "2015-01-01" @default.
- W2364652250 modified "2023-09-23" @default.
- W2364652250 title "Construction of Recombinant Adenovirus Ad-GFP-C197 and its Antitumor Activity" @default.
- W2364652250 hasPublicationYear "2015" @default.
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