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- W2364653457 abstract "Objective: To investigate the change and analysis the alteration of matrix metalloproteinase 3(MMP-3) and tissue inhibitors of matrix metalloproteinase 1(TIMP-1).Methods: 60 SD rats randomly divided into three groups.Group 1 and group 2 were given 4-nitroquinoline-1-oxide(4NQO) everyday.Group 3 drank normal saline everyday.Group 1 rats were sacrificed at 16 weeks.Group 2 rats were killed at 24 weeks.Ten rats of control group were killed at 16 weeks and others were killed at 24 weeks.Each sample was divided into two parts.One was underwent histological examination.The other was assayed the kinetics of MMP-3 mRNA and TIMP-1 mRNA expression.Results: Tumors were originated on rats of group given 4NQO at 24 weeks.No tumor originating was found in rats of group given normal saline.The mRNA expression of MMP-3 was increased high in the rats which were caught tongue epithelial dysplasia or tongue squamous cell carcinoma.Moreover,the rats with tongue squamous cell carcinoma showed a higher overregulated expression of MMP-3 than the rats only with tongue epithelial dysplasia.The mRNA expression of TIMP-1 was also overregulated in rats with disease compared to the normal rats.The related relationship of the mRNA expression for MMP-3 and TIMP-1 was significant from the normal rat to the rat with tongue squamous cell carcinoma.Conclusion: The significant imbalance of MMP-3 and TIMP-1 can lead to the occurrence and development of the tongue squamous cell carcinoma." @default.
- W2364653457 created "2016-06-24" @default.
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- W2364653457 date "2012-01-01" @default.
- W2364653457 modified "2023-09-28" @default.
- W2364653457 title "Analysis of Matrix Metalloproteinase 3 and Tissue Inhibitors of Matrix Metalloproteinase 1 in Tongue Squamous Cell Carcinoma Rat Model" @default.
- W2364653457 hasPublicationYear "2012" @default.
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