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- W2364653724 abstract "A study of injection megestrol acetate co. on the effect of pituitary-ovarian function was carried out in 4 healthy multiparous women. The serum levels of follicle stimularing hormone (FSH), luteinizing hormone (LH), prolactin (PRL), estradiol (E_2), progesterone (p) and cortisol (F) were assayed by RIA prior to treatment and at 1st, 6th and l2th treatment cycles. The hormonal profile before injection showed normal pituitary-ovarian function with ovulation-like change. During treatment the midcycle FSH-LH surges did not occur. The basal values of FSH at the beginning of each cycle were higher than those before treatment. 24h after injection E_2 increased and persisted at high level for about 5 days and then dropped down to low level The P levels were low throughout the whole cycle. PRL and F were in normal ranges. After treatment persistent high level of E_2 and LH rebound action could be seen. The above suggested that this injectable contraceptive has its effect of ovulation inhibition through suppression of midcycle peak of the gonadotrophic hormones. The follicular activity returned earlier than luteal activity. There were overian follicles developing in the ovaries. The rebound phenomenon of pituitary-ovarian function was present. The result of this study revealed that the effect of this injectable contraceptive on pitutaryovarian function is mild." @default.
- W2364653724 created "2016-06-24" @default.
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- W2364653724 date "1987-01-01" @default.
- W2364653724 modified "2023-09-24" @default.
- W2364653724 title "THE EFFECT OF MONTHLY INJECTABLE CONTRACEPTIVE MEGESTROL ACETATE COMPOUND ON PITUITARY-OVARIAN FUNCTION" @default.
- W2364653724 hasPublicationYear "1987" @default.
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