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- W2364658935 abstract "Objective To investigate the role of sinomenine on expression of renal transforming growth factorβ1(TGF-β1)in diabetic nephropathy(DN)rats to further understand the therapeutic effect of sinomenine on DN rats.Methods Fourty five healthy male SD rats were randomly divided into three groups:normal control(Group N),DN control(Group D)and sinomenine treated group(Group S),with fifteen rats in each group.The group S was treated with hypodermic injection of sinomenine [20 mg/(kg·d)],and the group D was given the same dose of sodium chloride.The role of sinomenine was estimated by measuring the changes of body weight,serum glucose and 24 hour urinary protein excretion every two weeks.Meanwhile,three rats in each group were randomly killed and the inferior vena blood and renal tissue were collected for determination of serum creatinine,observation of renal pathological section and reverse transcription polymerase chain reaction(RT-PCR)analysis of TGF-β1 mRNA expression.Results Compared with group N,the body weight gain in group D was significantly lowered,and 24 hour urinary protein excretion,serum creatinine lever and TGF-β1 mRNA expression in group D were significantly increased(P0.05).The body weight,24 hour urinary protein excretion and TGF-β1 mRNA expression in Group S were markedly improved compared with Group D(P0.05).There was no significant difference in serum creatinine level and pathologic changes between Group S and Group D(P0.05).The renal TGF-β1 mRNA exhibited positive correlation with 24 hour urinary protein excretion and serum creatinine level(r=0.892,P0.01;r=0.845,P0.01).Conclusion Sinomenine exerted an early renal protective role on DN rats involving inhibition of TGF-β1 expression." @default.
- W2364658935 created "2016-06-24" @default.
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- W2364658935 date "2009-01-01" @default.
- W2364658935 modified "2023-09-25" @default.
- W2364658935 title "Effects of Sinomenine on Transforming Growth Factor-β_1 Expression in Diabetic Rat Kidney" @default.
- W2364658935 hasPublicationYear "2009" @default.
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