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- W2364660898 abstract "Objective To investigate the association of β_ 3-adrenergic receptor (AR) gene polymorphism and environment factors (TV-watching) with weight gain in children. Methods Four-hundred children in elementary schools in Daqing were enrolled in the present study. Body height and weight were measured in 1 st, 5th year. The polymorphism of β_ 3-AR gene was detected by PCR-RFLP. The relationship between β_ 3-AR gene polymorphism and weight gain and the effect of genetic and environmental factors (TV-watching) on weight gain were analysed by multivariate regression analysis with SAS software package. Results (1) After adjustment for age and sex, the body weight of 5th year of TA/AA genotype group was significantly higher than that in TT group [(38.3±10.5)kg vs (36.3±8.3)kg, P0.05]. Stepwise regression analysis showed that the body weight of 5th year was positively correlated with baseline body weight, the time of TV-watching, TA/AA genotype. (2) When stratified all the subjects to threegroups(tertiles)bytimeof TV-watching (mean time was 2.3, 4.3 and 7.3 h respectively), the weight gain were (12.6±0.6)kg、(13.8±0.4)kg、(15.9±0.5)kg, the P value between 1st and 3 rd group was 0.01. Compared the weight gain between genotypes in three groups, weight gain of TA/AA genotype was significantly more than that of TT genotype (P0.05) group in which the time of TV-watching was 7.3 hours per week. Conclusions (1) β_ 3-AR gene polymorphism is significantly correlated with weight gain. (2) Environmental factors (time of TV-watching) enhance the effect of the genotype of β_ 3-AR TA/AA in promoting weight gain." @default.
- W2364660898 created "2016-06-24" @default.
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- W2364660898 date "2005-01-01" @default.
- W2364660898 modified "2023-09-28" @default.
- W2364660898 title "Effect of β_3-adrenergic receptor gene polymorphism and TV-watching on weight gain in children" @default.
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