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- W2364660904 abstract "AIM The effect of tetrandrine(Tet),a purified extract from Chinese herb Stephania tetrandra S Moore,on experimental liver fi-brosis in rats was studied.METHODS Hepatofibrosis model was induced in SD rats,by 40 % CCI4 1.2ml/kg body weight,subscutaneously,twice a week for 12 weeks From the first injection of CCL4 on,30mg of Tet(treatment group)or saline(control group)was given by stomach every 2 days for 12 weeks.The animals were sacrificed at 4,8,12 and 14 weeks respectively Serum procollagen type Ⅲ(PCⅢ),liver and serum hyaluronate(HA)were detected.The liver collagen,number of fat-storing cells(FSC)and its oranganelles were examined.RESULTS Tet could reduce the level of serum PCⅢ and HA and liver HA,and the deposition of liver collagen.At the end of the treatment,serum PCⅢ was 61.8±21.0 ug/L in Tet-treated rats and 270.2±46,1 ug/L in the control ones(P0.01)Uiver HA was 86.9±15.3 ug/g vs 186.5 + 46.2(P0.01).FSC and its endopiasmic reticulum and mitochondria were inhibitrd.CONCLUSIONS Tet is able to inhibit the deposition of collagen in the liver and it may be used as an antifibrostic agent in chronic liver diseases." @default.
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- W2364660904 date "1994-01-01" @default.
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- W2364660904 title "Prevention and treatment action of tetrandrine on experimental liver fibrosis in rats" @default.
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