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- W2364663048 abstract "AIM To investigate the effects of adenosine on action potential (AP), L type calcium channel current ( I Ca.L ), and ATP sensitive potassium current ( I K.ATP ) in guinea pig ventricular myocytes under simulated ischemic reperfused conditions. METHODS Action potential was recorded in guinea pig ventricular myocytes using standard intracellular microelectrode technique. Whole cell patch clamp technique was used to record currents. RESULTS Ado enhanced the abbreviation of APD with a patter of dose dependence in simulated ischemic and hypoxic guinea pig ventricular myocytes,and inhibited the recovery of APD during reperfusion. Under ischemic and hypoxic conditions, the amplitude of I Ca.L was greatly decreased. Ado did not aggravate the decrease of I Ca.L induced by ischemia and hypoxia. Reperfusion was accompanied by a slow return of I Ca.L toward preischemic values. Ado accelerated the activation of I K.ATP in ischemia. Values of I K.ATP in Ado (100 μmol·L -1 ) group were greater than that of control in both ischemia and reperfusion. CONCLUSION Ado significantly increased the abbreviation of APD in guinea pig ventricular myocytes under simulated ischemic and hypoxic conditions and delayed recovery of APD in reperfusion. The mechanism of effects of Ado on APD in ischemia and reperfusion was attributed to the increase in I K.ATP ." @default.
- W2364663048 created "2016-06-24" @default.
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- W2364663048 date "2003-01-01" @default.
- W2364663048 modified "2023-09-25" @default.
- W2364663048 title "Effects of adenosine on action potential and its ionic mechanisms in guinea-pig ventricular myocytes under simulated ischemic-reperfused conditions" @default.
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