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- W2364666722 abstract "Objective To investigate the dynamic change and their correlation of telomerase catalytic sub-unit TERT,proliferating cell nuclear antigen PCNA and Bcl-2 in the formation of epiretinal membranes of traumatic proliferative vitreoretinopathy.Methods S-P technique were applied for immunocytochemical staining of epiretinal membranes of traumatic PVR with TERT,PCNA and Bcl-2 antibody.HE staining was also carried out.The staining results were analyzed with image analysis system.Results The positive rate and average OD of PCNA protein increased at first and then decreased after operation.Compared with 7 days group and 28 days group,the positive rate in 14 days group was highest.The positive rate and average OD of TERT and Bcl-2 also increased at first and then decreased.Compared with 7 days group,the positive rate in 14 days group and 21 days group were higher.There was significant correlation among PCNA、Bcl-2 and TERT protein expression.Conclusions TERT and Bcl-2 paly roles in the regulation of proliferative cells in epiretinal membranes of traumatic proliferative vitreoretinopathy,and have high correlation with the dynamic change of cell proliferation.It provides experimental basis for preventing or treating PVR by gene technique such as antisense ribozyme and the choice of therapy time." @default.
- W2364666722 created "2016-06-24" @default.
- W2364666722 creator A5078822542 @default.
- W2364666722 date "2008-01-01" @default.
- W2364666722 modified "2023-09-25" @default.
- W2364666722 title "The Dynamic Expression of TERT,PCNA and Bcl-2 in Epiretinal Membrances in Experimentally Induced Proliferative Vitreretinopathy and their Relativity Study" @default.
- W2364666722 hasPublicationYear "2008" @default.
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