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- W2364669135 abstract "Aim To study the effects of osthole on blood lipid,estradiol(E2),lipoprotein lipase(LPL),hepatic lipase(HL)and their relationship.Methods Mice were orally given osthole 10~40 mg·kg-1 when hyperlipidemic model was induced.After 3 weeks,activities of LPL and HL and total cholesterol(TC),triglyceride(TG)and high density lipoprotein-cholesterol(HDL-C)levels in post-heparin plasma were determined.Normal mice were treated with osthole 10~40 mg·kg-1 for 1 week,the serum level of E2 was determined by an ELISA method.Ovariectomized rats were orally given osthole 10 mg·kg-1 for 12 weeks,then serum E2,TC and TG levels were measured.Results After treatment with osthole(10~20 mg·kg-1),post-heparin plasma activities of LPL and HL in high-fat diet mice and serum level of E2 in normal mice significantly increased(P0.05 or P0.01),plasma lev-els of TC,TG and low density lipoprotein-cholesterol(LDL-C)in high-fat diet mice decreased(P0.05 or P0.01),and HDL-C level increased(P0.01).When the dose of osthole increased to 40 mg·kg-1,the serum level of E2 further increased(P0.01),but activities of LPL and HL in post-heparin plasma in high-fat diet mice decreased,and the degree of decrease in plasma levels of TC,TG,LDL-C and increase in HDL-C level were also lowered as compared with low-dose osthole.After ovariectomized rats were treated with osthole 10 mg·kg-1 for 12 weeks,serum E2 obviously increased(P0.05),while TG level significantly decreased(P0.05),and serum level of TC also decreased in some degree.Conclusions Low-dose osthole could increase the blood level of E2 and the activities of LPL and HL,and result in decrease in the blood lipid.Though high-dose osthole could further increase the E2 level in blood,the activities of LPL and HL decreased and its lipid-modifying effect was attenuated as well." @default.
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- W2364669135 date "2007-01-01" @default.
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- W2364669135 title "Study of the effects of osthole on blood estradioland lipase in animals and their relationship" @default.
- W2364669135 hasPublicationYear "2007" @default.
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