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- W2364669493 abstract "Objective:To investigate the effects and clinical value of Hsp90-inhibitor Geldanamycin on TNF-induced upregulation of cFLIP.Methods:The influence of TNF and Geldanamycin(GA)+TNF-α on expression of cFLIP both at the mRNA and protein levels were investigated by RT-PCR and immunochemistry respectively.Results:The PC3M cells were treated with TNF-α(20ng/ml) for 6 h,TNF upregulated markly the expressoion of cFLIP both at the mRNA and protein levels.After the PC3M cells were treated with the indicated concentrations of GA for 18 h and then challenged futther with TNFα(20ng/ml) for 6 h,GA pretreatmeatment completely bloked TNF-induced upregulation of cFLIP both at the mRNA and protein levels.Conclusions:GA pretreatmeatment could completely block TNFinduced upregulation of cFLIP." @default.
- W2364669493 created "2016-06-24" @default.
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- W2364669493 date "2006-01-01" @default.
- W2364669493 modified "2023-09-25" @default.
- W2364669493 title "Influence of HSP90-inhibitor Geldanamycin on TNF-induced upregulation of cFLIP in PC-3M cells" @default.
- W2364669493 hasPublicationYear "2006" @default.
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