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- W2364671386 abstract "Objective: To study the effects of angiotensin converting enzyme inhibitors (ACEIs) on fibrinolysis in patients with essential hypertension. Methods: Examinations of systolic and diastolic blood pressure (SBP, DBP), echocardiography, renin, angiotensinⅡ(ATⅡ), aldosterone (ALD), plasminogen activator inhibitor (PAI-1) and tissue-type plasminogen activator (t-PA)were performed before and after the treatment of captopril in 31 patients with essential hypertension. Results: SBP and DBP were lower after the treatment than that before the treatment, and there was a significant difference (P 0.01). There was no significant difference in left ventricular ejection fraction, ALD and PRA pre- and post-treatment (P 0.05). The level of ATⅡ and PAI-1 after the treatment were lower than that before the treatment, and there was a significant difference (P 0.01). The ratio of PA / PAI-1 (activity) after the treatment was higher than that before the treatment, and there was a significant difference (P 0.05). There was a positive correlation between the activity of PAI-1 and the level of ATⅡ(r = 0.576,P 0.01). There was a positive correlation between the activity of PAI-1 and the level of ALD (r = 0.451, P 0.05) and DBP (r = 0.430, P 0.05). The level of t-PA had no relationship with each parameter. Conclusion: ACEIs has a beneficial effect to fibrinolysis, and can improve the endogenous fibrinolysis disturbance in patients with essential hypertension." @default.
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- W2364671386 date "2006-01-01" @default.
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- W2364671386 title "Effects of Captopril on Fibrinolysis in Patients with Essential Hypertension" @default.
- W2364671386 hasPublicationYear "2006" @default.
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