Matches in SemOpenAlex for { <https://semopenalex.org/work/W2364672671> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2364672671 abstract "Objective: To investigate the effects of 1,25-dihydroxy vitamin D3[1,25(OH)2D3] and all-trans retinoic acid(ATRA) on growth and cell cycle and apoptosis of human ovarian cancer cellsHO8910,and the expression of vitamin D receptor and the retinoic acid receptor α mRNA,then explore the molecular mechanism.Methods:HO8910 human ovarian cancer cell line were cultured in vitro and treaed with1,25(OH)2D3,ATRA,or the combination of both chemicals,cell proliferation was evaluated by MTT assay.Cell cycle and apoptosis were determined by flow cytometry(FCM).The expression of VDR and RAR α mRNA were determined by reverse transcription-polymerase chain reaction(RT-PCR).Results:The resulte showed that1,25(OH)2D3 and ATRA used alone or in combination,inhibited the growth of HO8910 cells in a time dependent manner(P0.05).FCM analysis indicated that1,25(OH)2D3 and ATRA used alone or in combination could change cell cycle of HO8910 cells(P0.05),increased the ratesofG1,induced apoptosis(P0.05).They could up-regulation of VDR and RAR α(P0.05),then inhibit proliferation of HO8910 cells.All of the effects were more obvious in the combination group than in 1,25(OH)2D3 or ATRA groups(P0.05).Conclusion:It is conclused that 1,25(OH)2D3 and ATRA could inhibit cell growth,change the cell cycle and induced G1 phase arrest of HO8910 cells,induce apoptosis,they could up-regulation of VDR or RAR α,then inhibit proliferation of HO8910 cells.Further more,the combination of1,25(OH)2D3 and ATRA could exert synergistic inhibitory efecton the growth of HO8910 cells." @default.
- W2364672671 created "2016-06-24" @default.
- W2364672671 creator A5049840665 @default.
- W2364672671 date "2011-01-01" @default.
- W2364672671 modified "2023-09-23" @default.
- W2364672671 title "SYNERGISTIC INHIBITORY EFFECT OF 1,25(OH)_2D_3 AND ATRA ON GROWTH OF HUMAN OVARIANCANCER CELL LINE HO8910" @default.
- W2364672671 hasPublicationYear "2011" @default.
- W2364672671 type Work @default.
- W2364672671 sameAs 2364672671 @default.
- W2364672671 citedByCount "0" @default.
- W2364672671 crossrefType "journal-article" @default.
- W2364672671 hasAuthorship W2364672671A5049840665 @default.
- W2364672671 hasConcept C105696609 @default.
- W2364672671 hasConcept C1491633281 @default.
- W2364672671 hasConcept C153911025 @default.
- W2364672671 hasConcept C170493617 @default.
- W2364672671 hasConcept C179639408 @default.
- W2364672671 hasConcept C185592680 @default.
- W2364672671 hasConcept C190283241 @default.
- W2364672671 hasConcept C2779707156 @default.
- W2364672671 hasConcept C2781121885 @default.
- W2364672671 hasConcept C29537977 @default.
- W2364672671 hasConcept C502942594 @default.
- W2364672671 hasConcept C54355233 @default.
- W2364672671 hasConcept C553184892 @default.
- W2364672671 hasConcept C55493867 @default.
- W2364672671 hasConcept C62112901 @default.
- W2364672671 hasConcept C81885089 @default.
- W2364672671 hasConcept C86803240 @default.
- W2364672671 hasConcept C95444343 @default.
- W2364672671 hasConceptScore W2364672671C105696609 @default.
- W2364672671 hasConceptScore W2364672671C1491633281 @default.
- W2364672671 hasConceptScore W2364672671C153911025 @default.
- W2364672671 hasConceptScore W2364672671C170493617 @default.
- W2364672671 hasConceptScore W2364672671C179639408 @default.
- W2364672671 hasConceptScore W2364672671C185592680 @default.
- W2364672671 hasConceptScore W2364672671C190283241 @default.
- W2364672671 hasConceptScore W2364672671C2779707156 @default.
- W2364672671 hasConceptScore W2364672671C2781121885 @default.
- W2364672671 hasConceptScore W2364672671C29537977 @default.
- W2364672671 hasConceptScore W2364672671C502942594 @default.
- W2364672671 hasConceptScore W2364672671C54355233 @default.
- W2364672671 hasConceptScore W2364672671C553184892 @default.
- W2364672671 hasConceptScore W2364672671C55493867 @default.
- W2364672671 hasConceptScore W2364672671C62112901 @default.
- W2364672671 hasConceptScore W2364672671C81885089 @default.
- W2364672671 hasConceptScore W2364672671C86803240 @default.
- W2364672671 hasConceptScore W2364672671C95444343 @default.
- W2364672671 hasLocation W23646726711 @default.
- W2364672671 hasOpenAccess W2364672671 @default.
- W2364672671 hasPrimaryLocation W23646726711 @default.
- W2364672671 hasRelatedWork W2005073338 @default.
- W2364672671 hasRelatedWork W2019557905 @default.
- W2364672671 hasRelatedWork W2089134614 @default.
- W2364672671 hasRelatedWork W2148743166 @default.
- W2364672671 hasRelatedWork W2348535119 @default.
- W2364672671 hasRelatedWork W2351131295 @default.
- W2364672671 hasRelatedWork W2372147482 @default.
- W2364672671 hasRelatedWork W2372814069 @default.
- W2364672671 hasRelatedWork W2375343956 @default.
- W2364672671 hasRelatedWork W2379704312 @default.
- W2364672671 hasRelatedWork W2391518070 @default.
- W2364672671 hasRelatedWork W2409858545 @default.
- W2364672671 hasRelatedWork W2442470032 @default.
- W2364672671 hasRelatedWork W2465485980 @default.
- W2364672671 hasRelatedWork W2571439391 @default.
- W2364672671 hasRelatedWork W2574629575 @default.
- W2364672671 hasRelatedWork W2980238836 @default.
- W2364672671 hasRelatedWork W3029433168 @default.
- W2364672671 hasRelatedWork W3030251054 @default.
- W2364672671 hasRelatedWork W3084283392 @default.
- W2364672671 isParatext "false" @default.
- W2364672671 isRetracted "false" @default.
- W2364672671 magId "2364672671" @default.
- W2364672671 workType "article" @default.