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- W2364673537 abstract "Objective To investigate the influence of high glucose or/and insulin on expression of several signaling molecules of vascular smooth muscle cells and the molecular mechanism of diabetes mellitus complicated by hypertension.Methods Cultured vascular smooth muscle cells from rat were randomly divided into the following groups:control,high glucose(HG),high insulin(HI),high glucose and high insulin(HG+HI),high glucose and normal insulin(HG+NI) and normal insulin(NI).Western blot was used to detect the expression of iNOS、eNOS、RhoA、ROCK-1 of each group.The fluorescence microscope was used for the detection of intracellular Ca~(2+) level.Results The expression of iNOS or eNOS in HG group was decreased,in contrast,the intracellular Ca~(2+) level and the expression of RhoA or ROCK-1 were increased.In HI group,the expression of iNOS or eNOS was increased,while the intracellular Ca~(2+) level was reduced and the expression of RhoA or ROCK-1 had no change.In NI group,iNOS or eNOS expression was increased,while the others were same as those in control group.In HG+HI group or HG+NI group,insulin had the effect against the impact of glucose on vascular smooth muscle cells.Conclusion High glucose has an injurious effect on relaxation and contraction of VSMC,while insulin can conteract this effect." @default.
- W2364673537 created "2016-06-24" @default.
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- W2364673537 date "2006-01-01" @default.
- W2364673537 modified "2023-09-24" @default.
- W2364673537 title "Effect of high glucose and high insulin on signaling molecules of relaxation and contraction of vascular smooth muscle cells" @default.
- W2364673537 hasPublicationYear "2006" @default.
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