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- W2364679032 abstract "Objective To study the impact of single dose mitomycin C on vessel and fibroblasts in pterygium,and to study its treatment mechanism on pterygium.Methods 1.The pterygium cases were divided into two groups:group A,group B.In group A,pterygiums were directly cut and specimens of pterygiums were kept for pathological study.In group B,single dose MMC,which is 0.1ml from 0.4mg/ml,was injected into pterygiums through their necks preoperatively.Pterygium resections were done 3 to 10 weeks after injection and specimens were kept for pathological study as well.Group C,5 eyes were observed from normal balbar conjunctiva with other eye diseases but without pterygium.2.specimens from group A,B and N were made into paraffin sections respectively with HE staining to observe changes of vessel and fibroblasts.Results 1.Vascular disappeared or became thinner,congestion of the pterygium body decreased with different degrees of vascular contraction in pterygium after using MMC.2.The number of blood vessels reduced in the head and body of the pterygium in group B under optical microscope.Small blood vessels shrank near the basement membrane.Fibroblasts reduced and the cell body wane with deep staining and irregular shape nuclear,less clear cytoplasm.More blood vessels were found in group A and B with pterygiums compared with Group C,and these blood vessels scattered.The number of blood vessels in the head and body of pterygium in group A was significantly different(P0.05) compared with group B as well.Some patients outset the symptom of eye pain after using MMC,and the symptoms relieved one week after using Indomethacin orally or by eye drops.There were no complications because of MMC in MMC using group.Conclusion 1.The number of blood vessels and fibroblasts increased significantly in pterygium than that in normal conjunctiva.2.MMC can depress blood vessels and fibroblasts in pterygium.There were no serious eye complications with using low concentration and low dose of MMC." @default.
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- W2364679032 date "2009-01-01" @default.
- W2364679032 modified "2023-09-24" @default.
- W2364679032 title "The impact of single dose mitomycin C on vessel and fibroblasts in pterygium" @default.
- W2364679032 hasPublicationYear "2009" @default.
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