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- W2364681008 abstract "Objective: To investigate effects of different penetration enhancers on in vitro transdermal absorption ability of infantile diarrhea gel ointments. Method: Drug transdermal instrument was adopted to investigate percutaneous penetration of infantile diarrhea gel ointments,acceptable solution was selected by single factor test,and then 24 h in vitro total cumulative permeation and cumulative transmittance of evodiamine and retaecarpine in infantile diarrhea gel ointments were investigated after adding different content( 1%,3%,5%) azone,oleic acid,propylene glycol. HPLC was adopted to determine contents of evodiamine and retaecarpine by taking acetonitrile-water( 51∶ 49) as mobile phase and detection wavelength of 225 nm. Result: Within 24 h,cumulative transmittance of evodiamine and retaecarpine in blank sample was 34. 53%,in samples containing different amounts of azone were 33. 92%,34. 78% and 34. 65%,in samples containing different contents of oleic acid were 33. 67%,34. 57% and 34. 57%,in samples containing different contents of propylene glycol were 34. 49%,34. 61% and 34. 53%,respectively. Conclusion: Volatile components from infantile diarrhea gel ointments had promotion role of drug penetration." @default.
- W2364681008 created "2016-06-24" @default.
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- W2364681008 date "2014-01-01" @default.
- W2364681008 modified "2023-09-28" @default.
- W2364681008 title "Effects of Penetration Enhancers on Percutaneous Penetration of Infantile Diarrhea Gel Ointments" @default.
- W2364681008 hasPublicationYear "2014" @default.
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