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- W2364682400 abstract "Objective To investigate the role of mitochondrial Smac/Diablo and XIAP in ATP depletion/recovery-induced apoptosis in renal tubular epithelial cells. Methods To induce apoptosis, HK-2 cells were transiendy exposed to metabolic inhibitor for 90 min followed by recovery. Apoptosis was detected by Hoechst33342 staining. The release of Smac/Diablo was examined by indirect immunofluorescence. Cytosolic fraction was extracted to detect the level of Smac/Diablo by Western blot. Total protein was extracted to measure the protein level of XIAP and pro-caspase-3. Results After ATP depletion/recovery in HK-2 cells, Hoechst33342 staining showed nucleus condensation and apoptotic body conformation. Indirect immunofluorescence revealed the release of Smac/Diablo. Western blot showed the increased level of Smac/Diablo in cytosolic fraction and the decreased level of XIAP and pro-caspase-3 after ATP depletion/recovery. Conclusion Smac/Diablo release from mitochondria and decreased level of XIAP in HK-2 cells after ATP depletion/recovery may play an important role in apoptosis through caspase-dependent pathway." @default.
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- W2364682400 date "2006-01-01" @default.
- W2364682400 modified "2023-09-28" @default.
- W2364682400 title "Role of Smac/Diablo and XIAP in ATP depletion/recovery-induced apoptosis in renal tubular epithelial cells" @default.
- W2364682400 hasPublicationYear "2006" @default.
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