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- W2364689274 abstract "OBJECTIVE: To study the protective effects of Fuke zaizao pills (FKW) on hysteromyoma model rats. METHODS: Model rats were divided into 6 groups, i.e. normal control group, model group,Guizhi fuling capsule group (0.3 g·kg-1) and FKW high-dose, medium-dose and low-dose groups(1.12,0.56,0.28 g·kg-1). The uterine leiomyoma-like hyperplasia model rats were induced by estrogen and progesterone load method. The pathological changes of uterus were observed. The expression of estrogen and progesterone receptors in smooth muscle cells and the level of serum estrogen and progesterone were measured. RESULTS: Compared with normal control group, hysterauxesis of model group was more significant, and the serum level of E2 and P and the expression of ER and PR in the model group increased obviously(P0.01). Compared with model group, the serum level of E2 and P in FKW high-dose, medium-dose and low-dose groups decreased significantly, and the expression of ER and PR of smooth muscle cells decreased significantly (P0.05 or P0.01). CONCLUSION: The results suggest that FKW have the function of resisting uterine leiomyoma-like hyperplasia in rats, which may be related to the regulation of serum level of E2 and P,the inhibition of the expression of ER and PR of smooth muscle cells." @default.
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- W2364689274 date "2012-01-01" @default.
- W2364689274 modified "2023-09-28" @default.
- W2364689274 title "Protective Effects of Fuke Zaizao Pills on Hysteromyoma Model Rats" @default.
- W2364689274 hasPublicationYear "2012" @default.
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