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- W2364689693 abstract "To investigate the protective effects of angiotensin (1 7) [Ang (1 7)] in acute myocardial ischemia induced by isoprenaline in rats. Ninety six Wister rats were randomized to four groups as follow: ①control, ②perindopril, ③Ang (1 7), ④perindopril+Ang (1 7), 24 rats in each group. Peritoneal injection with isoprenaline (10 mg·kg-1) to prepare the model of acute myocardial ischemia, at the same time, perindopril was started orally with 2 mg·kg-1·d-1 and intravenous infusion of angiotensin (1 7) was started continuously with 25 μg·kg-1·h-1 by implanted osmotic minipumps in the treatment groups, isometric saline was started intravenously in control group. Forty eight hours, 7 days, and 14 days after treatment, 8 rats were killed separately, the carotid artery systolic and diastolic blood pressure, heart rate were measured before executing, and plasma was taken for determination of creatine kinase (CK), lactic dehydrogenase (LDH), superoxide dismutase (SOD), at last the percentage of total myocardial infarction volume in whole myocardium volume was measured. Isoprenaline induced area of myocardial infarction,blood pressure,heart rate, CK,LDH increased, and SOD decreased, P 0.05. After 48 hours treatment, area of myocardial infarction, blood pressure, heart rate, CK and LDH decreased, and SOD increased in perindopril and Ang (1 7) groups, this advantage was obviously significant with the treatment time prolonged. In 14 days, the percentage of total myocardial infarction volume in whole myocardium volume in control, perindopril, Ang (1 7), and perindopril+Ang (1 7) groups were (9.8±0.6)%,(5.9±0.5)%,(5.6±0.3)%, and (4.2±0.3)%, respectively. Compared to the control group, the difference was significant, P 0.05. There was no difference between perindopril and Ang (1 7) groups using single drug, but perindopril+Ang (1 7) group (both drugs using together) had synergistic effect. [Conclusion]Angiotensin (1 7) has the effect of myocardial protection. Its efficacy is the same of perindopril. The effect is more prominent in using both drugs." @default.
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- W2364689693 date "2004-01-01" @default.
- W2364689693 modified "2023-09-26" @default.
- W2364689693 title "Effects of Angiotensin-(1-7) on Acute Myocardial Ischemia Induced by Isoprenaline in Rats" @default.
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