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- W2364692508 abstract "OBJECTIVE: To investigate the proliferation and apoptosis of human gastric cancer SGC7901 cell induced by ApoG2 in vitro.METHODS: By using 3.125,6.250,12.500,25.000 and 50.000 μmol/L concentrations of ApoG2 to treat SGC7901 cells for 24,48 and 72 h,the inhibitory rate of cell proliferation was assessed by MTT method.After 24 h treated with 10,20 and 30 μmol/L ApoG2,MGG staining was used to investigate the cells morphological changes.Flow cytometry(FCM) was used to determine the cellular apoptosis with 10,20,30 and 40 μmol/L ApoG2.The expressions of Bcl-2,Bax and NF-κB mRNA were measured by RT-PCR with 10,20 and 30 μmol/L ApoG2.RESULTS: The inhibitory rate of SGC7901 cells treated with ApoG2 were higher than those in the negative control group(P0.05) with concentration-dependent,and the half inhibitory(IC50) were 32.58,25.11 and 14.16 μmol/L at 24,48 and 72 h;With the increasing of drug concentration,cells became slow,cytoplasm became loose,nuclei were darker,nucleoplasm ratio increased and cells presented typical cells death form.Apoptosis could be seen under flow cytomtry,after 24 h of ApoG2,early apoptosis rates were(1.92±0.55)%,(3.36±0.55)%,(5.07±0.70)%,(7.44±1.47)% and(7.88±1.22)%,and late apoptosis rates were(2.80±0.86)%,(13.09±0.93)%,(16.48±1.03)%,(18.32±1.44)% and(25.49±1.59)%,with the increase of ApoG2 with 0,10,20,30 and 40 μmol/L,the apoptosis rate of SGC7901 cells was increased(P0.01);The RT-PCR result showed that the expression levels of Bcl-2 and NF-κB mRNA were decreased(P0.05) with the increase of ApoG2,while the expression of Bax mRNA was up-regulated(P0.05).CONCLUSION: ApoG2 can inhibit the proliferation of SGC7901 cells and induce the apoptosis in vitro." @default.
- W2364692508 created "2016-06-24" @default.
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- W2364692508 date "2013-01-01" @default.
- W2364692508 modified "2023-09-24" @default.
- W2364692508 title "Effects of ApoG2on proliferation and apoptosis of gastric cancer cells SGC7901" @default.
- W2364692508 hasPublicationYear "2013" @default.
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