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- W2364692560 abstract "Objective To investigate the expression of insulin-like growth factor-1(IGF-1), vascular endothe lial growth factor(VEGF) in cervix morbid change and their clinical significance. Methods The expression of IGF-1, VEGF were detected by immunohistochemisty(EnVisionTM) in 30 patients of chronic cervicitis and 70 patients of malignant lesion. Results The positive expression rate of IGF-1 protein was 3.33% in chronic cervicitis and61.43% in cervical squamous-celled carcinoma, with statistically significant difference(χ2=28.77, P0.01). The expression rate of VEGF protein in chronic cervicitis and cervical squamous-celled carcinoma was 0%, 48.57%, respectively with statistically significant difference(χ2=22.08, P0.01). The expression of IGF-1 and VEGF were related to tumor size, lymph node metastasis, distant place organ metastasis and FIGO staging(P0.05), but not to age and histological type(P0.05). There was significantly positive correlation between IGF-1 and VEGF(r=0.59, P0.01) in cervical squamous-celled carcinoma tissue. Conclusion IGF-1 and VEGF are over-expressed in cervical squamous-celled carcinoma tissue, which are both involved in the occurrence and development of cervical squamous-celled carcinoma.Therefore, the detection of IGF-1 and VEGF is helpful for judging the prognosis of patients." @default.
- W2364692560 created "2016-06-24" @default.
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- W2364692560 date "2013-01-01" @default.
- W2364692560 modified "2023-09-25" @default.
- W2364692560 title "Expression of IGF-1, VEGF in cervix morbid change and their clinical significance" @default.
- W2364692560 hasPublicationYear "2013" @default.
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