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- W2364693236 abstract "Objective To detect whether insulin increase the radiosensitivity of a549 lung adenocarcinoma cells in vitro.Methods Insulin was add directly to the cultrueed A549 cells in vitro,followed by X-ray exposure of these cells to accelerator linear.And methyl thiazolyl tetrazolium(MTT) and flow cytometry were used to observe apoptosis of A549 lung adenocarcinoma cells.Results MTT indicated that there was no significant difference of optical density(OD)value between cells with and without insulin(P0.05).But the rate of apoptosis was significant different between cells with insulin and without insulin(P0.05).Among them,there was obvious difference between 4、8、16 mU/mL insulin group and control group(P0.01).Conclusion Insulin of different concentration could not promote the proliferation of A549 cells perpetually and insulin could increase the radiosensitivity and promote apoptosis of these cells.These results could provide some underlaying evidence for the use of insulin as sensitizer of radiotherapy in clinical treatment." @default.
- W2364693236 created "2016-06-24" @default.
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- W2364693236 date "2008-01-01" @default.
- W2364693236 modified "2023-09-25" @default.
- W2364693236 title "The Research about Insulin Increasing the Radiosensitivity of A549 Lung Adenocarcinoma Cells" @default.
- W2364693236 hasPublicationYear "2008" @default.
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