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- W2364693419 abstract "Objective To study the relationship between the C-106T polymorphism in aldose reductase (AR)gene and the susceptibility of retinopathy in type 2 DM and the linkage of the C-106T polymorphism with (AC)n repeat polymorphic marker at the 5'end of AR gene. Methods 116 patients with type 2 DM were divided into no diabetic complication (NDC) group and diabetic retinopathy(DR)group. PCR were performed using genomic DNA as template. PCR products were digested with restriction enzyme Bfα. Genotypes were determined by electrophresis on 3% agarose gel using gel documentation and analysis system. Results Two alleles C/T and three genotypes CC,CT and TT were found. The frequency of CC genotype was significantly higher in DR group than that in NDC group (64.0% vs 43.9%, P0.05) and the frequency of CT genotype was significantly lower in DR group than that in NDC group (30.0% vs 54.0%, P0.01). The frequency of Z-2/C haplotypes was significantly higher in DR group than that in NDC group (37.0% vs 3.0%, P0.001) and the frequency of Z+2/C and Z+2/T haplotype was significantly lower in DR group than that in NDC group (11.0% vs 42.0%, P0.01 and 2.0% vs 14.0%, P0.05 respectively). Conclution CC genotype might increase the susceptibility of DR whereas CT genotype might decrease the susceptibility of DR. The C-106T polymorphism and the (AC)n polymorphism might be in linkage disequilibrium." @default.
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- W2364693419 date "2003-01-01" @default.
- W2364693419 modified "2023-09-22" @default.
- W2364693419 title "The study on the relationship between the c-106t polymorphism in aldose reductase gene promoter region and the susceptibility of retinopathy in type 2 diabetes mellitus" @default.
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