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- W2364693963 abstract "Objective To study the relationship between plasma homocysteine(Hcy) and lower extremity atherosclerotic disease(LEAD) in the elderly patients.Methods A total of 217 elderly patients were selected in sequence,which were divided into normal group and lower extremity atherosclerotic disease(LEAD) group according to the ankle-brachial index(ABI).The medical history including smoking,hypertension,diabetes,hyperlipidemia,coronary heart disease and stroke was recorded.The biochemical indicators including Hcy,creatinine(Cr),uric acid(UA),cystatin C(Cys-C),total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C) and blood pressure(BP),body mass index(BMI),abdominal circumference were collected.And laboratory parameters in each group were retrospectively analyzed using multiple regression analysis.Results The age,gender,abdominal circumference,BMI,diastolic blood pressure(DBP),Cr,Cys-C,fasting blood glucose(FBG),TC,TG,LDL-C and the history of high blood pressure,diabetes,hyperlipidemia of the two groups were no significantly difference(P 0.05).Hcy,UA,systolic blood pressure(SBP) and pulse pressure(PP) were significantly higher in the LEAD group than those in the normal group(P 0.05).And there were significantly more patients who had the history of smoking,coronary heart disease or stroke in the LEAD group(P 0.05).ABI and HDL-C were significantly lower in the LEAD group than those in the normal group(P 0.05).Multiple regression analysis showed that Hcy was positively associated with LEAD(P 0.05).Conclusions The high hyperhomocysteinemia(HH) is an important risk factor of cardiovascular disease,which should be intervened actively." @default.
- W2364693963 created "2016-06-24" @default.
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- W2364693963 date "2013-01-01" @default.
- W2364693963 modified "2023-09-24" @default.
- W2364693963 title "The relationship between homocysteine and lower extremity atherosclerotic disease in the elderly patients" @default.
- W2364693963 hasPublicationYear "2013" @default.
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