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- W2364700120 abstract "Objective To explore the relationship between the 5-hydroxytryptamine(5-HT) and its receptor gene(HTR2A)-1438A/G or tryptophan hydroxylase gene(TPH1)-6526A/G polymorphism or other factors and the intelligence in children with attention deficit hyperactivity disorder(ADHD).Methods Three hundred and sixty-six Chinese Han descent ADHD children,ascertained according to the Diagnostic and Statistical Manual of Mental Disorders the 4th edition(DSM-Ⅳ) were included.The quantitative traits of psychometric intelligence quotient(IQ) were calculated by the Chinese Wechsler Intelligence Scale for Children(C-WISC).All subjects′ genotypes of polymorphism of HTR2A gene-1438A/G and TPH1 gene-6526A/G were identified with the restriction fragment length polymorphism me-thod.The demographical information on the family including parent′s educational attainment level was gathered.ADHD children were divided into 3 groups according to the genotypes,such as GG,GA and AA.ADHD children were also divided into 3 groups according to the parent′ educational attainment levels.Results The average scores [including the Full Scale IQ(FIQ),and Verbal Scale IQ(VIQ)] did significantly differ among different groups defined by genotypes of HTR2A gene-1438A/G polymorphism(F=5.238 P=0.006;F=6.052 P=0.003).ADHD children with GG genotype of HTR2A gene-1438A/G polymorphism performed significantly better on FIQ and VIQ than did children with GA and AA genotypes[P(FIQ)=0.003,0.042;P(VIQ)=0.001,0.032].There were no significant differences among the 3 genotypes of TPH1 gene-6526A/G polymorphism.Father′s educational attainment level would contribute to both the FIQ and VIQ of 3 ADHD groups(F=3.664 P=0.027;F=5.261 P=0.006).Mother′s educational attainment level would contribute to the FIQ and VIQ of 3 ADHD groups(F=4.894 P=0.008;F=5.043 P=0.007).Through the multifactor linear regression analysis,genotype of HTR2A gene-1438A/G polymorphism and mother′s educational attainment level were the major factors which influence FIQ and VIQ of ADHD children.Conclusion HTR2A gene-1438A/G polymorphism and mother′s educational attainment level may be associated with the intelligence of ADHD children in China." @default.
- W2364700120 created "2016-06-24" @default.
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- W2364700120 date "2009-01-01" @default.
- W2364700120 modified "2023-09-23" @default.
- W2364700120 title "Influence of Serotonin Gene Polymorphism on Intelligence of Children with Attention Deficit Hyperactivity Di-sorder" @default.
- W2364700120 hasPublicationYear "2009" @default.
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