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- W2364702208 abstract "Objective To study the hepatoprotective effect of Limonium sinense(Girard)Ktze root extract(LSE)and the possi- ble mechanisms underlying its protection on acute liver injury induced by carbon tetrachloride(CCl_4).Methods CCl_4-induced liver injury model was used to evaluate the effect of LSE on the activities of serum aspartate aminotransferase(AST)and alanine aminotransferase(ALT)in mice.Ultrastructure of liver was observed and liver mitochondrial membrane potential and mitochon- drial swelling were measured following CCl_4 injection without or with LSE.Results With oral pretreatment of 100 mg/kg,200 mg/kg or 400 mg/kg LSE,the increase in serum AST and ALT activities induced by CCl_4 were obviously reversed and significant morphological changes in liver mitochondria were remarkably lessened.In addition,the decrease in mitochondrial membrane po- tential and sensitivity of mitochondrial swelling to the exotic Ca~(2+)stimulation induced by CCl_4 were also prevented by LSE.Con- dusion LSE has hepatoproteetive activity and the mechanisms underlying its protective effect may be related to its protection on liver mitochondria." @default.
- W2364702208 created "2016-06-24" @default.
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- W2364702208 date "2007-01-01" @default.
- W2364702208 modified "2023-09-25" @default.
- W2364702208 title "Experimental Study on Protection of Limonium sinense Ktze Root Extract against Acute Liver Injury Induced by Carbon Tetrachloride" @default.
- W2364702208 hasPublicationYear "2007" @default.
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