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- W2364703350 abstract "ObjectiveTo observe the expression of Fas/FasL and Bcl-2/Bax correlated with apoptosis in synoviocyte of adjuvant arthritis(AA) with artesunate.MethodsSixty wistar rats were randomly divided into six groups:normal group,model control group,artesunate group I(high dose),artesunate group II(low dose),artesunate plus MTX group,MTX group.Each group was modeled to adjuvant arthritis with complete Freund's.After treated with artesunate or artesunate plus MTX,the arthrosis index(AI),the expression of Fas/FasL,Bcl-2,Bax,which were correlated with apoptosis in arthrosis synovial membrane tissue were examined by immunohisto chemistry(IHC).ResultsCompared with the model control group,the AI in every experiment group decreased significantly(P0.01).Compared with the model control group,the expression of Fas/FasL,Bax in arthrosis synovial membrane tissue increased significantly(P0.05),Bcl-2 decreased significantly(P0.05).ConclusionThe effect of artesunate on the alleviation of adjuvant arthritis(AA) was proved in experiment,inducing apoptosis in synoviocyte was likely one of mechanisms." @default.
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- W2364703350 date "2006-01-01" @default.
- W2364703350 modified "2023-09-27" @default.
- W2364703350 title "The Experimental Research on the Expression of Fas/FasL and Bcl-2/Bax Correlated with Apoptosis in Synoviocyte of Adjuvant Arthritis with Artesunate" @default.
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