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• W2364709612 abstract "<h3>BACKGROUND AND PURPOSE:</h3> The presence of the <i>apolipoprotein E</i> ε<i>4</i> allele is the strongest sporadic Alzheimer disease genetic risk factor. We hypothesized that <i>apolipoprotein E</i> ε<i>4</i> carriers and noncarriers may already differ in imaging patterns in midlife. We therefore sought to identify the effect of <i>apolipoprotein E</i> genotype on brain atrophy across almost the entire adult age span by using advanced MR imaging–based pattern analysis. <h3>MATERIALS AND METHODS:</h3> We analyzed MR imaging scans of 1472 participants from the Study of Health in Pomerania (22–90 years of age). We studied the association among age, <i>apolipoprotein E</i> ε<i>4</i> carrier status, and brain atrophy, which was quantified by using 2 MR imaging–based indices: Spatial Pattern of Atrophy for Recognition of Brain Aging (summarizing age-related brain atrophy) and Spatial Pattern of Abnormality for Recognition of Early Alzheimer Disease (summarizing Alzheimer disease-like brain atrophy patterns), as well as the gray matter volumes in several Alzheimer disease- and <i>apolipoprotein E</i>–related ROIs (lateral frontal, lateral temporal, medial frontal, and hippocampus). <h3>RESULTS:</h3> No significant association was found between <i>apolipoprotein E</i> ε<i>4</i> carrier status and the studied ROIs or the MR imaging–based indices in linear regression models adjusted for age, sex, and education, including an interaction term between <i>apolipoprotein E</i> and age. <h3>CONCLUSIONS:</h3> Our study indicates that measurable <i>apolipoprotein E</i>–related brain atrophy does not occur in early adulthood and midlife and suggests that such atrophy may only occur more proximal to the onset of clinical symptoms of dementia." @default.
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• W2364709612 date "2016-05-12" @default.
• W2364709612 modified "2023-10-18" @default.
• W2364709612 title "Relationship between<i>APOE</i>Genotype and Structural MRI Measures throughout Adulthood in the Study of Health in Pomerania Population-Based Cohort" @default.
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• W2364709612 doi "https://doi.org/10.3174/ajnr.a4805" @default.
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