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- W2364709834 abstract "To investigate the expression of testosterone and androgen receptor in the testicle tissue of kidney yang deficient mouse as well as the effects of icariin in kidney yang deficiency models,mice were injected with hydrocortisone intraperitoneally for 15 days,and then treated with three different doses of icariin for additional 15 days. Radioimmunoassay. Immunohistochemistry and real-time RT-PCR were used to measure serum testosterone,androgen receptor ( AR ) proteins and mRNA levels in testicle tissue. Our results showed that model group was significant ( P 0. 05) lower in body weights and the serum testosterone levels as compared to the normal group. The testosterone in the high,medium-dose oficariin,and methyl-testosterone treated groups was not different from that of the normal group ( P 0. 05). In the low dose icariin-treated group,the testosterone was lower than the normal group,butsignificantly higher than the model group. In the testicle,AR-immunostaining and AR mRNA were bothreduced in the model group (P 0. 05),whereas the low,medium icariin,and the methyl-testosterone dosed groups did not change significantly (P 0. 05),except the high dose icariin group which showed a higher AR and mRNA levels in the testicle tissue than the models ( P 0. 05). This study suggested that the reduced serum testosterone,androgen receptor mRNA and protein levels in the kidney yang deficient mice could be reversed with the icariin treatments." @default.
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- W2364709834 date "2011-01-01" @default.
- W2364709834 modified "2023-09-25" @default.
- W2364709834 title "Icariin Rescues the Downregulated Testosterone and Testicle Androgen Receptor Expression in Kidney Yang Deficient Mice" @default.
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