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- W2364722458 abstract "Objective To investigate the effects of losartan on fibrinolysis in 34 essential hypertension patients.Methods Thirty-four patients with essential hypertension were given losartan for 4 weeks.Systolic and diastolic blood pressure(SBP,DBP),heart rate(HR),concentration of plasminogen activator inhibitor(PAI-1) and tissue-type plasminogen activator(t-PA) were measured before and after losartan treatment.Thirty healthy persons were taken as control group.Results Before treatment,plasma t-PA level was lower and PAI-1 level was higher in hypertension group than in control group(P0.01).After losartan treatment,the SBP and DBP were both significantly decreased(P0.01) in hypertension group,while the HR and the t-PA level did not change.The PAI-1 level was decreased and the ratio of tPA/ PAI-1 was increased significantly(both P0.01).Conclusions There is endogenous fibrinolysis disturbance in essential hypertension patients and losartan therapy can improve the fibrinolytic activity." @default.
- W2364722458 created "2016-06-24" @default.
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- W2364722458 date "2007-01-01" @default.
- W2364722458 modified "2023-09-26" @default.
- W2364722458 title "Effects of losartan therapy on fibrinolysis in essential hypertension patients" @default.
- W2364722458 hasPublicationYear "2007" @default.
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