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- W2364725086 abstract "Objective To investigate the effects of epidural dexamethasone on the postoperative analgesia induced by epidural neostigmine and morphine and on its complications.?Methods Sixty patients (ASA scaleⅠ~Ⅱ) undergoing abdominal surgery were randomly assigned to group N and group ND. Group N was given 1 mg neostigmine and 1 mg morphine in 10-ml saline via epidural catheter 30 min before the end of operation, Group ND was given equal volume saline solution containing 5 mg dexamethasone in addition to equal contents of neostigmine and morphine. At 4 h, 8 h, 12 h, 24 h and 48 h after operation, the score of pain and incidences of postoperative nausea and vomiting (PONV), urinary retention and bradycardia, were recorded.?Results The scores of pain 4 h, 8 h, 12 h and 24 h after operation showed no significant differences between the two groupsa, but at 48h after operation, the difference was significant, with the scores being 3.6±1.5 in group ND and 5.2±2.1 in group N. The incidence of PONV in group ND was significantly lower than in group N in the whole postoperative course.?Conclusion Epidural administration of dexamethasone can significantly strengthen the analgesic effect and decrease the incidence of PONV of neostigmine and morphine." @default.
- W2364725086 created "2016-06-24" @default.
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- W2364725086 date "2002-01-01" @default.
- W2364725086 modified "2023-09-25" @default.
- W2364725086 title "Epidural administration of dexamethasone combined with neostigmine and morphine for postoperative analgesia" @default.
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