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- W2364728669 abstract "Objective: To screen genes with abnormal expression in lung squamous cell carcinoma with cDNA chip. Methods: The mRNA was extracted from cancer tissue and normal lung tissue, and was labeled by Cy5-dCTP or Cy3-dCTP as probes. Then the mixed probes were hybridized to cDNA chip containing 4 096 genes and genes with different expressions between lung squamous cell carcinoma and normal lung tissue were screened. Results: Two hundred and twenty-five genes were differentially expressed between squamous cell carcinoma and normal lung tissue. Compared with normal lung tissue, 116 genes were up-regulated and 109 genes were down-regulated in cancer tissue. Among the 37 genes with remarkable differential expression between the two tissues, 24 were up-regulated and 13 down-regulated. Conclusions: Many genes are possibly involved in the initiation and progression of human lung squamous cell carcinoma. cD-NA chip technique might be a useful method in screening lung cancer implicated genes." @default.
- W2364728669 created "2016-06-24" @default.
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- W2364728669 date "2005-01-01" @default.
- W2364728669 modified "2023-09-23" @default.
- W2364728669 title "DNA chip analysis of genes with different expression patterns between lung squamous cell carcinoma and normal lung tissue" @default.
- W2364728669 hasPublicationYear "2005" @default.
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