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- W2364730808 abstract "OBJECTIVE A reversed phase high performance liquid chromatography has been established for determinating concentration of the active metabolite of tazanolast and studying its pharmacokinetics in human urine.METHODS After a single oral dose (75 mg) of tazanolast capsules were given to 8 healthy male volunteers, the urine samples were withdrawn up to 16 h and the active metabolite of tazanolast concentration in urine was assayed by RP HPLC. The excretion data in urine were disposed by sigma minus method.RESULTS The pharmacokinetic parameters were as follows: t 1/2 was( 1.8 ± 0.6 )h, X u ∞ was ( 28.8 ± 7.7 ) mg, P % was( 48.0 ± 10.6 )%?CONCLUSIONS This method is simple, precise and useable for pharmacokinetic studies of tazanolast in human being." @default.
- W2364730808 created "2016-06-24" @default.
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- W2364730808 date "2002-01-01" @default.
- W2364730808 modified "2023-09-25" @default.
- W2364730808 title "Pharmacokinetics of tazanolast capsule in human urine after administration of a single oral dose" @default.
- W2364730808 hasPublicationYear "2002" @default.
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