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- W2364732024 abstract "Objective To evaluate the effect of capsaicin on the symptom and examination in adult patients with allergic rhinitis and to explore new pathophysiological mechanisms of allergic rhinitis.Methods Search for all the related literature in MEDLINE and CBMdisc has been made.Randomised-controlled trials (RCTs) or controlled clinical trials(CCTs) for capsaicin were collected.Measurement variables included nasal symptoms,albumin and leukocyte counts in nasal lavage fluids,responsiveness to histamine and rhinitis quality of life.Results There was one paper with better quality on designing.Capsaicin did have a small effect on the area of the curve of histamine dose response curves(P=0.03).No significant effect of capsaicin on other outcomes was demonstrated.There were 3 papers with lower research quality on treatment.Capsaicin treatment reduces different degrees of allergic symptoms.Atropine,Colchicine and Lidocaine prevent the tendency of capsaicin to irritate nerve in different degrees.With dosage of Capsaicin increasing,nasal symptoms,albumin and leukocyte counts in nasal lavage fluids increased.Conclusion Capsaicin did have a small effect on the area of the curve of histamine dose response curves and improvement of the symptoms needs more research to be confirmed.Neurogenic inflammation plays an important role in pathogensis of allergic rhinitis." @default.
- W2364732024 created "2016-06-24" @default.
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- W2364732024 date "2005-01-01" @default.
- W2364732024 modified "2023-09-24" @default.
- W2364732024 title "Evidence-based Assessment of Capsaic in for Allergic Rhinitis in Adults" @default.
- W2364732024 hasPublicationYear "2005" @default.
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