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- W2364741118 abstract "AIM:To study the protective effect of Ginkgo Biloba extract (GBE) on gastric mucosa.METHODS:By means of restraint cold stress (RCS) in rats and absolute ethanol gavage in mice,the index of gastric mucosa injury was evaluated.After the gastric juice was collected with the method of pyloric ligation the volume and acidity of this juice,and activity of pepsin were determined.And the content of malondialdydehyde (MDA) in gastic mucosa and serum was measured by thiobarbituric acid (TBA) method.RESULTS:GBE (25,50 and 100mg/kg×2/d×5d ig) inhibited dose dependently the gastric mucosa injury induced by RCS and absolute ethanol gavage.The indexes of gastric mucosa injury after RCS in groups pretreated with GBE were 58.1%,43.0% and 31.2% of control group respectively.The indexes of gastric mucosa injury induced by ethanol in groups pretreated with GBE decreased to 61.5%,36.1% and 25.6% of control group respectively.And GBE enchanced the protective effects of Cimetidine (Cim) on gastric mucosa.But it didn't obviously influence the volume and acidity of gastric juice as well as activity of pepsin.After ig (absolute ethanol) for 1 hr,the contents of MDA in gastric mucosa and serum of mice significantly increased vs control group ( P 0.01).But pretreatment with GBE (25,50 and 100mg/kg ig) could significantly inhibited the increase of MDA formation induced by absolute ethanol both in gastric mucosa and serum.CONCLUSION:GBE has protective effect on gastric mucosa and GBE plus Cim possess the synergism in the treatment of gastric ulcer.These effects may be related to its antioxidant action." @default.
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- W2364741118 date "1999-01-01" @default.
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- W2364741118 title "Protective Effect of Ginkgo Biloba Extract on Gastric Mucosa" @default.
- W2364741118 hasPublicationYear "1999" @default.
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