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- W2364741681 abstract "Objective: To investigate the effect of total Saponins of Panax ginseng (TSPG) on bone marrow macrophage (BMMφ)and its relationship with hematopoiesis regulation. Methods: The hematopoietic progenitor cell and macrophage were cultured ex vivo, and the hematopoietic growth factor (HGF) in culture media of BMMφ was assayed. Immunocytochemistry and nucleic acid in situ hybridization of HGF were also used. Results: (1) The conditioned culture media of BMMφ induced by TSPG significantly enhanced the development of CFU-Mix , CFU-E , CFU-GM at different levels. (2)The expressions of EPO, GM-CSF,IL-3, IL-6 protein in BMMφ induced by TSPG were much stronger than those of the control. (3)The expression of EPO mRNA, GM-CSF mRNA in BMMφ induced by TSPG were also intensified. Conclusion: TSPG may directly and/or indirectly stimulate the BMMφ in hematopoietic inductive microenvironment to synthesize and secrete hematopoietic growth factors such as EPO, GM-CSF, IL-3 and IL-6, which in turn promote the proliferation and differentiation of CFU-Mix, CFU-E and CFU-GM." @default.
- W2364741681 created "2016-06-24" @default.
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- W2364741681 date "2004-01-01" @default.
- W2364741681 modified "2023-09-23" @default.
- W2364741681 title "Effect of total Saponins of Panax ginseng on bone marrow macrophage and its relationship with hematopoiesis regulation" @default.
- W2364741681 hasPublicationYear "2004" @default.
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