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- W2364743616 abstract "【Objective】To study the effects of quercetin on the expression of cytochrome c in leukemia cell.【Methods】K562 cells were cultured in vitro and the morphology of neuleus was observed by Hoechst33342/PI staining,The mitochondrion and cytoplasm of K562 cells treated by 4×10~(-5) mol/L quercetin were separated and the expression of Cyt C.was measured by SDS-PAGE and Western bloting.【Results】When the concentrations of quercetin were 2×10~(-5) mol/L,4×10~(-5) mol/L and 8×10~(-5) mol/L,the growth of cells was inhibited remarkably in a dose-dependent manner.Fluorescence staining showed obvious apoptosis,such as karyopyknosis and agglutination.Western bloting showed that the expression of Cyt C in cytoplasm was significantly increased.【Conclusion】Quercetin could inhibit the growth of leukemia cell lines K562 in vitro by means of apoptosis mediated by down-regulating the expression of Cyt C in mitochondrion." @default.
- W2364743616 created "2016-06-24" @default.
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- W2364743616 date "2006-01-01" @default.
- W2364743616 modified "2023-09-24" @default.
- W2364743616 title "Expression of cytochrome C in apoptotic leukemia cell K562 induced by quercetin" @default.
- W2364743616 hasPublicationYear "2006" @default.
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