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- W2364747095 abstract "Objectives:To investigate the association of immune inflammation with total prostate volume and androgen receptor expression in benign prostatic hyperplasia(BPH).Methods:One hundred and five surgery-derived prostate specimens were analyzed retrospectively.Immune inflammation was defined by CD4 or CD8 marker positive expression on immunohistochemistry(IHC).IHC markers were CD4 and CD8 decorating T-lymphocytes,and androgen receptor(AR) antibody decorating androgen receptor in BPH samples.Total prostate volumes(TPV) and AR expression associated with immune inflammation were analyzed.Results:The rate of CD4,CD8 and AR expression in BPH was 20(19.0%),21(20.0%) and 48(45.7%),respectively.Total prostate volume was significantly higher in the immune inflammation group compared to the non-immune inflammation group(67.0 cm~3 vs.54 cm~3;t=2.32,P0.05).There was a significant difference in AR expression between immune inflammation group and non-immune inflammation group(X~2=7.35,P0. 05).The rate of AR expression in the immune inflammation group was higher than the non one(65.6%vs.37.0%).Conclusions:The strong association of immune inflammation with TPV and AR expression in BPH tissue was demonstrated.Prostate hypertrophy due to immune inflammatory process may progressively conduce to BPH progression.Therefore,anti-inflammation is a therapeutic target for BPH." @default.
- W2364747095 created "2016-06-24" @default.
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- W2364747095 date "2011-01-01" @default.
- W2364747095 modified "2023-09-25" @default.
- W2364747095 title "Correlations of Immune Inflammation with Total Prostate Volume and Androgen Receptor Expression" @default.
- W2364747095 hasPublicationYear "2011" @default.
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