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- W2364752365 abstract "Objective To explore the earliest time,position and characteristics of the opening BBB in the early stages of severely scalded rabbits.Methods Forty-two rabbits were randomized into control、1、2、2.5、3 and 4h groups after scald injury.The rabbits in wounded groups were inflicted with 50% TBSA of Ⅲ degree skin scald. 125 I labeled bovine serum albumin ( 125 I-BSA) was used as tracer to observe the earliest time point and position of opening of BBB after severe scald.The results were compared with the changes of ultrastructure by electronic microscopic.Results 125 I-BSA intake began to increase remarkably at 2.5 hour in anterior cortex and cerebellum,and it became increase remarkably at 3 hour in all parts of the brain.Histological changes of BBB were observed as early as 2 hour after scald,accompanied by swelling of basal lamina and glial cell.The tight junction of blood vessel endothelial cell began to loose and became vague at 3 hour after scald.Conclusion The earliest opening of BBB is at 2 hour after scald,and the position is at cerebellum and anterior cortex.These facts suggest that the impairment of BBB would aggravate in a diffuse and progressive way. 125 I-BSA is sensitive and precise to monitor the permeability of BBB." @default.
- W2364752365 created "2016-06-24" @default.
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- W2364752365 date "2005-01-01" @default.
- W2364752365 modified "2023-09-27" @default.
- W2364752365 title "Dynamic research of the opening of blood-brain barrier in the early stage of severely scalded rabbits" @default.
- W2364752365 hasPublicationYear "2005" @default.
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