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- W2364753207 abstract "Objective To evaluate the antibacterial activity in vitro of linezolid against gram-positive cocci: Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus heamolyticus, Enterococcus faecalis, Entero-coccus faecium, etc. and to provide evidence for rational use of antibiotics. Methods VITEK-32 and ATB mi-crobial analysis systems were performed to identify 257 strains of gram-positive cocci and analyze the antibacte-rial activities of 8 antibiotics against staphylococci and Enterococci. Results 111 strains of staphylococcus au-reus including 74 strains of MRSA, 96 strains of coagulase-negative staphylococci among which MRCNS account-ed for 86.0%, 45 strains of Enterococcus faecalis and 13 Enterococcus faecium were observed in 257 clinical isolates. The sensitive rates of linezolid against Staphylococci and Enterococci were 100% and 93.1% respective-ly, which were the same as vancomycin and higher than other common used antibiotics (such as erythromycin, cefazolin and ciprofloxacin). The MIC50 and MIC90 of linezolid against staphylococcus aureus, coagulase-nega-tive staphylococci and Enterococci were 1, 1mg/L; 1, 1mg/L and 2, 4mg/L, respectively. Conclusions Clinical isolate rates of methicillin-resistant staphylococci with severe multi-drug resistance are common. Linezolid just like vancomycin have strong antibacterial activity against Staphylococci and Enterococci which show different drug-resistance to levofloxacin, tetracycline and erythromycin." @default.
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- W2364753207 date "2009-01-01" @default.
- W2364753207 modified "2023-09-24" @default.
- W2364753207 title "A study of antibacterial activity in vitro of linezolid against gram-positive cocci" @default.
- W2364753207 hasPublicationYear "2009" @default.
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