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- W2364754013 abstract "OBJECTIVE To investigate the protective effect of Yulangsan flavonoids(YF) on myocardial ischemia reperfusion injury(MIRI) in Sprague Dawley(SD) rats.METHODS Sixty healthy Sprague Dawley rats were randomly divided into the Sham operation(Sham) group,the MIRI group,the normal saline(NS) group,the three pretreated groups(YF low dose group,YF medium dose group and YF high dose group),with half female and half male rats in each group.Rat's MIRI model was established by ligating left anterior descending coronary artery for 30 min followed by reperfusion for 60 min.Different dosages of YF were administered 30 min before ligating left anterior descending coronary artery in every pretreated group.Blood was collected at the end ofreperfusion for detecting the serum to observe the changes of aspartate aminotransferase(AST),lactate dehydrogenase(LDH),lactate dehydrogenase isoenzyme 1(LDH1),superoxide dismutase(SOD),malondialdehyde(MDA).The myocardial infarct size was measured after reperfusion.RESULTS YF preconditioning could significantly decrease the contents of AST,LDH,LDH1 and MDA,and the myocardial infarct size,and increase the activities of SOD.CONCLUSION YF has a significant protective effect on myocardial ischemia reperfusion injury in rats." @default.
- W2364754013 created "2016-06-24" @default.
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- W2364754013 date "2008-01-01" @default.
- W2364754013 modified "2023-09-25" @default.
- W2364754013 title "Protective effect of Yulangsan flavonoids on myocardial ischemia reperfusion injury in rats" @default.
- W2364754013 hasPublicationYear "2008" @default.
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