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- W2364755462 abstract "Objective To analyze T-cell receptor excision DNA circles (TRECs) level and TCR Vβ repertoire usage and clonality, evaluating the thymic recent output function and the expansion feature of TCR Vβ subfamily T cells in patients with acute myelogenous leukemia M5 subtype (AML-M5). Methods Quantitative detection of TRECs in DNA of peripheral blood mononuclear cells (PBMC) from 5 cases with AML-M5 were preformed by real-time PCR (TaqMan) analysis. And the TRECs-number was related to the number of T-cells by determination of the number of CD3-positive cells. The expression and cloanlity analysis of TCR Vβ subfamilies were detected by RT-PCR and genescan technique in PBMC from the same patients. 9 normal individuals served as controls. Results In compare with normal individuals (6.84±4.71 copies /1000 CD3 +cells,p0.05), a dramatic reduction of TRECs values in patients with AML-M5 (0.76±1.21 copies /1000 CD3 +cells) could be found. The expression of 2-16 Vβ subfamilies was found in samples from 5 patients. Genescan analysis showed that clonal expanded T cells from 4 cases could be identified in some Vβ subfamily. Vβ1, Vβ15 and Vβ21 clonal T cells were detected in 3 cases. Conclusion This is, to our knowledge, the first description of TRECs level in AML-M5 patients. The result showed a prominent reduction of thymic output naive T cells function in AML-M5. The predominant usage and clonal expansion of TCR Vβ subfamily T cells could be identified in AML-M5 patients, indicating the host could have the ability for specific immune response to leukemia associated antigen, in despite of T cell immunodeficiency was showed in patients." @default.
- W2364755462 created "2016-06-24" @default.
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- W2364755462 date "2004-01-01" @default.
- W2364755462 modified "2023-09-25" @default.
- W2364755462 title "Naive T Cell Level and TCR Vβ Repertoire Usage in Patients with AML-M5" @default.
- W2364755462 hasPublicationYear "2004" @default.
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