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- W2364756932 abstract "Objective To study the target binding of chitosan nanoparticles with glycyrrhizin surface modification to hepatic parenchymal cells in vitro. Methods Flow cytometry was used to study the binding and intake capability of hepatocytic cells to chitosan nanoparticles labeled with rhodamine B isosulfocyanic acid (RBITC-CS-NPs) or to chitosan nanoparticles modified with glycyrrhizin (RBITC-CS-NPs-GL) on the surface. Results Compared with the control group,the size of the cells got enlarged and the number of granules in cytoplasm increased after the combination of hepatic parenchymal cells with RBITC-CS-NPs or RBITC-CS-NPs-GL.The fluorescence intensity expression in the cells combined with RBITC-CS-NPs-GL was higher than that in the cells combined with RBITC-CS-NPs.After being exposed to different concentrations of RBITC-CS-NPs or RBITGCS-NPs-GL,the transfection rate of hepatic parenchymal cells to RBITC-CS-NPs-GL was markedly higher than that to RBITC-CS-NPs especially at the concentration of 25μg·mL-1and 50μg·mL-1(P0.01).The intake of the nanoparticles by the cells was saturated at 300 g·mL-1 and 500μg·mL-1,and the transfection rate was over 90%. At the initial phase of the combination of RBITC-CS-NPs-GL with the cells(within one hour),their active targeting binding mediated by glycyrrhizin was obvious. Conclusion There is a combination site of glycyrrhizin on the surface of hepatic parenchymal cells,and chitosan nanoparticles with glycyrrhizin surface modification may enhance the hepatic-targeting transportation of the drug-containing carrier through the mediation of glycyrrhizin." @default.
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- W2364756932 date "2008-01-01" @default.
- W2364756932 modified "2023-09-22" @default.
- W2364756932 title "Targeting Binding of Chitosan Nanoparticles with Glycyrrhizin Surface Modification to Hepatic Parenchymal Cells in Vitro" @default.
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